diff --git a/bindings/pyroot/pythonizations/test/tseqcollection_itemaccess.py b/bindings/pyroot/pythonizations/test/tseqcollection_itemaccess.py
index 5d6a1e26c28cc..57b15334edfad 100644
--- a/bindings/pyroot/pythonizations/test/tseqcollection_itemaccess.py
+++ b/bindings/pyroot/pythonizations/test/tseqcollection_itemaccess.py
@@ -125,6 +125,10 @@ def test_setitem(self):
         with self.assertRaises(TypeError):
             sc[1.0] = ROOT.TObject()
 
+        # Clear before the added element might be garbage collected,
+        # to avoid dangling pointer access.
+        sc.Clear()
+
     def test_setitem_slice(self):
         sc1 = self.create_tseqcollection()
         sc2 = self.create_tseqcollection()
@@ -239,6 +243,8 @@ def test_delitem(self):
         with self.assertRaises(TypeError):
             del sc[1.0]
 
+        sc.Clear()
+
     def test_delitem_slice(self):
         # Delete all items
         sc1 = self.create_tseqcollection()