diff --git a/openmc/deplete/d1s.py b/openmc/deplete/d1s.py
index e9f8bfe79d6..311bc2d69cd 100644
--- a/openmc/deplete/d1s.py
+++ b/openmc/deplete/d1s.py
@@ -243,7 +243,7 @@ def prepare_tallies(
         for f in tally.filters:
             if isinstance(f, openmc.ParticleFilter):
                 if list(f.bins) == ['photon']:
-                    tally.filters.append(filter)
+                    if not tally.contains_filter(openmc.ParentNuclideFilter):
+                        tally.filters.append(filter)
                     break
-
     return nuclides
diff --git a/tests/unit_tests/test_d1s.py b/tests/unit_tests/test_d1s.py
index 115759489aa..9410f2da2e0 100644
--- a/tests/unit_tests/test_d1s.py
+++ b/tests/unit_tests/test_d1s.py
@@ -84,6 +84,11 @@ def test_prepare_tallies(model):
     assert tally.contains_filter(openmc.ParentNuclideFilter)
     assert sorted(tally.filters[-1].bins) == sorted(radionuclides)
 
+    assert len(tally.filters) == 2
+    # calling prepare_tallies twice should not add another ParentNuclideFilter
+    d1s.prepare_tallies(model, chain_file=CHAIN_PATH)
+    assert len(tally.filters) == 2
+
 
 def test_apply_time_correction(run_in_tmpdir):
     # Make simple sphere model with elemental Ni